Experiment

Experiment

A.005

Experiment

Regulation of cell growth and differentiation in microgravity: Signal transduction by growth factor receptors.

Primary investigator

S.W. de Laat

Co-investigator

W. Kruijer, R. de Groot

Contact point

Hubrecht Laboratory (NIOB)

Category

Life Sciences

Main research area

Developmental Biology

Keywords

Epidermal Growth Factor (EGF)
Differentiation
A431 Carcinoma Cells

Abstract

A0051101

Results

Transcriptional activation of the proto-oncogenes c-fos and c-jun is detectable within minutes of EGF treatment. Previously we have shown, that EGF-induced expression of c-fos is decreased under simulated microgravity conditions, whereas hypergravity showed the opposite effect. To extend these observations, we performed similar .... (full text)

Experiment

CIS-1 3A (CELLS A)

Funding agency

ESA

Launcher

Maser sounding rocket

Mission

Maser-3

Facility

Cells In Space (CIS)

Duration

420 sec.

Pictures

General

Related experiments:

De Laat on Maser-4

Verkleij on Maser-3

Verkleij on Maser-4