Experiment

Experiment

A.012

Experiment

The role of microgravity in the production of local growth factors involved in the bone cell function.

Primary investigator

Veldhuijzen, J.P.

Co-investigator

Van Loon, J.J.W.A.

Contact point

VU-ACTA-DeptOralCellBiol

Category

Life Sciences

Main research area

Bone biology

Keywords

Tissue cultures
Bone
Mineralisation
Resorption
Disuse
Disuse osteoporosis
Cartilage

Abstract

During 1990 the preparations were initiated to participate in the unmanned Soviet Bion-10 mission. In this experiment also fetal mouse long bones are used. The main purpose is to study histologically the mineralization and resorption after 3 and 6 days of .... (full text)

Subject of investigation

The influence of the mechanical environment on bone and cartilage growth and differentiation andthe role of a local growth factor TGF-a.

Subject name

A histological investigation of mineralisation and resorption of bone and cartilage matrix.

Standard method

Tissue culture

Results

Launch in november 1992

Experiment

Bion-10 experiment Bones

Funding agency

SRON and NWO

Launcher

Soyuz

Platform

BION

Mission

BION-10

Duration

Microgravity time : 4 days
Culture time : 4 days
Automated hardware: no crew time.

Equipment

- CCM plunger boxes (CCM-PB) with gas permeable foil in CIS-boxes flushed with 5% CO2/air.
- Control 1*g reference in CCM-PB inside ESA-Type I container.

Operational Constraints

Temperature 37 °C, gas phase in CIS-box must be 5% CO2/air

Other parameters

Activation time of the plungers, temperature data, pressure data.

Pictures

BION-10 logo

General

Related Experiments:

Veldhuijzen on IML-1